Head of Medicinal Chemistry & Early Research

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Ridgeline Discovery seeks an experienced drug discovery leader to strengthen its RNA focused small molecule efforts and help launch portfolio companies. The ideal candidate has 15+ years in the industry, a PhD in Medicinal Chemistry or related field, and a track record of leading small molecule programs to candidate nomination with strong SAR and synthetic chemistry skills, preferably RNA-targeted discovery. You will shape pipeline strategy, mentor an early research team, manage CRO partnerships, and collaborate with biology and translational teams to ensure efficient progression. To apply, tailor your CV and cover letter to highlight leadership, data driven decision making, IP expertise, and impact potential; include references and Basel onsite.

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Ridgeline Discovery, a Versant Ventures Discovery Engine, creates and operates Versant-financed innovative biotech companies in partnership with entrepreneurs, industry, and leading academics across Europe. In recent years, Ridgeline has assembled an international team of >50 highly experienced drug discovery and industry professionals and built and operated multiple new successful companies; these companies have raised significant funds through Series B, IPO and an exit through a trade sale.

We are seeking an experienced and entrepreneurial drug discovery leader to strengthen and expand our RNA-focused small molecule discovery efforts and support the launch of new portfolio companies.
The ideal candidate has a strong track record of leading and executing small molecule medicinal chemistry programs, with additional experience in RNA-targeted drug discovery considered a strong advantage.
The successful candidate will operate at the intersection of science and company-building, shaping pipeline strategy, building capabilities, and ensuring capital-efficient progression of programs from target identification through candidate nomination.

RESPONSIBILITIES

• Define and execute RNA-focused small molecule discovery strategies.
• Lead medicinal chemistry efforts across hit-to-lead and lead optimization.
• Develop robust SAR strategies and data-driven decision frameworks.
• Advance structured RNA-targeting approaches, including collaboration on assay and structural biology development.
• Build and mentor a high-performing early research team.
• Drive scientific strategy and execution across RNA-focused early discovery programs, partnering closely with biology and translational teams.
• Manage and oversee CRO and external research partnerships.
• Contribute to scientific discussions related to asset progression and platform differentiation.
• Represent the company at scientific conferences, board meetings, and investor presentations.

EDUCATION & EXPERIENCE

• PhD in Medicinal Chemistry, Organic Chemistry, or related discipline.
• 15+ years of pharmaceutical or biotech drug discovery experience.
• Proven track record of leading small molecule programs to candidate nomination.
• Experience in RNA-targeted small molecule discovery strongly preferred.
• Strong understanding of SAR strategy and synthetic chemistry.
• Familiarity with biophysical RNA-binding assays and structural biology.
• Strong understanding of intellectual property strategy and patent authorship.

PERSONAL PROFILE

• Entrepreneurial mindset and ability to operate in early-stage biotech environments.
• Strategic thinker with hands-on execution capability.
• Strong cross-functional collaborator and communicator.
• Decisive, data-driven, and outcome-oriented.

WHAT WE CURRENTLY OFFER

• People: We are an international, diverse, and highly collaborative team of talented, passionate, and science-driven individuals.
• Creativity: We offer an innovative and creative environment where new ideas are encouraged and cutting-edge science thrives.
• Development: We support the individual development of our employees.
• Impact & Entrepreneurship: Opportunity to help build and shape new biotech companies with direct impact on value creation.
• Innovation Platform: Opportunity to shape and expand a differentiated RNA-targeted discovery platform.
• Strategic Involvement: Direct involvement in key scientific and strategic decisions.
• Fun: From time-to-time we organise cool off-site summer and winter team events.
• Offices: Our well-equipped laboratories and offices are located at the Tech Park, a premier address for early-stage start-ups in Basel.
• Commuter Benefits: We support our employees tailored to their personal needs in commuting to work and offer parking facilities or a commuter contribution.
• Flexible Working: We support flexible working as appropriate.
• Christmas Closure: In addition to the 24 holidays per year, our offices/labs are closed between Christmas and New Year.
• Birthday Retreat: On top of that, your birthday is your personal holiday - our employees enjoy their birthday with a day off.

To apply, please submit your completed application form along with your CV, cover letter, and reference letters.