Scientist, Flow Sorting and Histology (Maternity Coverage)

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Quotient Therapeutics seeks a motivated biologist to advance its cell identification and isolation platform during a maternity coverage period, focusing on tissue structures and cell types across chronic and acute diseases. The ideal candidate has five years in flow cytometry and cell sorting, tissue dissociation optimization, spectral flow antibody panel design, and histology including immunofluorescence and immunohistochemistry, plus HTA experience. In a fast moving team you will design protocols, liaise with CROs, and supervise junior staff with precise record keeping. To apply, tailor your resume to quantify achievements, highlight regulatory and collaboration skills, and show Benchling or Notion and Jira experience, demonstrating a proactive, positive mindset for onsite Cambridge role.

Company Summary:

Quotient Therapeutics Ltd is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.

The company was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Generate Biomedicines, Sana Biotechnology (SANA), Tessera Therapeutics, Evelo Biosciences (EVLO), Indigo Agriculture, Seres Therapeutics (MCRB), and Syros Pharmaceuticals (SYRS). We are an equal opportunity employer.

Position Summary:

We are seeking a motivated, enthusiastic biologist to support the development of Quotient’s cell identification and isolation platform. The role involves understanding the biology of various chronic and acute diseases, in particular the tissue structures and cell types involved, and developing protocols for the identification and isolation of cell populations from human tissue. The successful candidate will be a self-starter, able to thrive in a fast-paced, cross-functional team environment and have a clear passion for somatic genomics. They will have demonstrated evidence of agility in their scientific work and an overt attitude of positivity when facing challenges. They will be dedicated to learning and development, embrace feedback and be open to working outside their comfort zone.

Key Responsibilities:

• Be an active member of the assay development team, conducting bench-based experiments.

• Design or adapt tissue dissociation and cell/nuclei isolation methods
• Develop new protocols for cell/nuclei isolation using fluorescent activated sorting techniques,
• Design and optimise new cell type specific antibody panels.
• Design or adapt imaging methods such as histological staining and immunofluorescence to identify tissue structures and cells of interest across a diverse range of human tissues.
• Engage external consultants to understand relevant tissue structures and appropriate identification methods. Liaise with contract research organisations (CROs) to outsource work as appropriate.
• Provide supervision and training for more junior lab members and/or technicians.

• Maintain compliance with regulatory requirements and quality standards, including the Human Tissue Act and COSHH.

• Maintain detailed experimental records and communicate key findings to stakeholders across the company, both in written and presentation formats.
• Collaborate closely with other team members across the organisation.

Key Skills and Experience:

Essential

• BSc or MSc degree in biochemistry, molecular biology or microbiology, or a related field.
• A minimum of 5 years' hands-on experience of flow cytometry and cell sorting, including multispectral.
• Experience with optimisation of tissue dissociation methods.
• Experience in the design and validation of antibody panels for spectral flow cytometry.
• Proficiency in histological techniques including tissue preparation, staining and data analysis.

• Experience with optimisation of immunofluorescence and immunohistochemistry protocols.

• Experience of working withhuman tissues under HTA regulations.
• Excellent communication skills, both written and verbal.
• Use of laboratory information management systems (Benchling preferred).

Desirable

• Experience in the isolation and sorting of nuclei.
• Experience with next generation sequencing library preparation and other downstream molecular biology processing.
• Experience in a biotech or pharmaceutical industry setting.
• Experience working with digital productivity tools such as Notion, Trello or Jira.

About Flagship

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognised twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognise there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.