Scientist - HTS Oligo Synthesis

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Merck's Scientist for HTS Oligo Synthesis in Billerica MA leads oligonucleotide synthesis, purification and ASO/siRNA processing in the Oligonucleotide Therapeutics Group. The role requires hands on use of Expedite, ABI, and Mermade synthesizers, HPLC and HPLC MS, desalting and lyophilization, plus meticulous electronic lab notebook practices and strong reagent inventory management. Qualifications include a PhD in chemistry, biochemistry or related field, or a Master’s with 3+ years in oligo work, or a Bachelor with 5+ years. Preferred: solid understanding of oligonucleotide chemistry and purification techniques. This onsite role does not offer sponsorship; external applicants must be eligible to work in the US, with a pay range of 94,400 to 141,600 plus benefits. To apply, tailor your resume to highlight relevant instruments, emphasize fast paced collaboration, and demonstrate precise documentation and troubleshooting.

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This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US. 

Your Role: 

EMD Serono in Billerica, MA is seeking a Scientist – HTS Oligo Synthesis to add to their Oligonucleotide Therapeutics Group (DDTech).

Responsibilities:

• Synthesis of oligonucleotides, deprotection, purification, desalting and lyophilization of oligonucleotides
• Operate Expedite/ABI/Mermade synthesizers and HPLC systems
• Prepare oligonucleotide synthesis reagents and synthesize, process, and purify ASO/siRNA using automated instruments by anion-exchange and reverse-phase HPLC systems
• Desalt, concentrate, and lyophilize final Oligo’s material using appropriate instrumentation or techniques
• Maintain a well-documented laboratory notebook and follow the safe laboratory practices
• Operate and troubleshoot available instruments including HPLC and MS
• Maintain an electronic laboratory notebook and miscellaneous documentation and maintain reagent inventory

Who You Are: 

Minimum Qualifications:

• PhD in Chemical Engineering, Chemistry, Biochemistry or other Science discipline

OR

• Master’s degree in Chemical Engineering, Chemistry, Biochemistry or other Science or Engineering discipline with 3+ years of experience in oligonucleotide field

OR

• Bachelor’s degree in Chemical Engineering, Chemistry, Biochemistry or other Science or Engineering discipline with 5+ years of experience in oligonucleotide field

Preferred Qualifications:

• Good understanding of Oligonucleotide chemistry

• Experience with a wide range of Oligo purification/analytical techniques, especially HPLC and/or HPLC-MS

• Experience performing desalting by using gel filtration or membrane filtration techniques
• High degree of flexibility and motivation in a fast-paced work environment

Pay Range for this position: $94,400 – $141,600 

The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information click here

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