Head of In Vitro ADME Bioassay Automation

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Merck MilliporeSigma in Billerica, MA is hiring a Head of In Vitro ADME Bioassay Automation to lead automated, high throughput in vitro assays (ADMET, biochemical and cell-based pharmacology) and to manage the automation team, driving data quality, reproducibility and regulatory compliance. You’ll shape the automation roadmap, collaborate with scientists and external partners, and implement scalable LC‑MS workflows for large data sets. Ideal candidates hold a PhD and 10+ years in pharma, biotech or CRO with proven leadership, ADMET and cell model experience, and a background in lab automation. To apply, tailor your resume to demonstrate leadership and throughput gains, include a concise cover letter, and show collaboration and English fluency; pay range is $137,400 to $206,100 with benefits.

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Head of In Vitro ADME Bioassay Automation

Company Overview:
A career with MilliporeSigma is an ongoing journey of discovery: our 60,000 people are shaping how the world lives, works, and plays through next generation advancements in healthcare, life science and performance materials. For more than 350 years and across the world we have passionately pursued our curiosity to find novel and vibrant ways of enhancing the lives of others.

Position Overview:
We are seeking a highly motivated and experienced Head of In Vitro ADME Bioassay Automation to lead our automation initiatives within the in vitro assay laboratory. This role is crucial for enhancing our assay capabilities through innovative automation solutions, ensuring high-quality results that support our research and development goals. You will be responsible for the development and implementation of bioassays (ADMET assays, biochemical, & cell-based pharmacology assays) in an automated and high throughput manner. Together with the research scientists of your laboratory, you will establish and run the assays being used for the characterization of small molecules in different phases of preclinical Drug Discovery. Furthermore, you will scout and establish novel assays or technologies within our organization. You will work as a delegate of the Bioassay team in cross-functional project teams as well as in a customer focused role.

Key Responsibilities:

• Establish lab operational processes and automated assay workflows with a focus on high throughput, data quality, and reproducibility of results.
• Lead and manage the in vitro bioassay automation team including designing & developing assays, analyzing large LC-MS / pharmacology datasets ensuring high standards of performance, quality, and compliance with industry regulations.
• Work with internal and external collaborators and ensure data delivery to agreed timelines.
• Collaborate with cross-functional teams and align automation strategies to delivery objectives.
• Drive continuous improvement initiatives within the laboratory, leveraging data and performance metrics to optimize processes.
• Mentor and develop laboratory staff, fostering a culture of innovation, collaboration, and excellence.
• Define the strategic roadmap for advancements in assay automation technologies and methodologies, integrating them into laboratory practices as appropriate.
• Ensure compliance with all safety, regulatory, and quality standards within the laboratory environment.

Preferred Qualifications:

• PhD in a relevant scientific discipline (e.g., Biology, Cell Biology, Molecular Biology, Biochemistry, or other related science discipline)
• At least 10 years' experience in Pharma industry, Biotech or CRO.
• Experience with designing, executing, and analyzing ADMET (absorption, distribution, metabolism, excretion, and toxicity), biochemistry, cell biology, or cell-based pharmacology assays.
• Experience with handling advanced cell culture models such as organoids, patient derived materials preferred.
• Experience in laboratory automation and management with expertise in developing and optimizing in vitro assays for different drug target classes
• Experience in compound characterization in a higher throughput fashion, using automation and data analysis
• Strong leadership skills with a proven ability to supervise research scientists
• Excellent analytical and problem-solving abilities, with a focus on data-driven decision-making.
• Effective communication skills, capable of collaborating across various departments and with external partners, while maintaining a strong customer-centric mindset
• Excellent presentation skills, a good networker and communicator.
• Fluency in English is mandatory

What We Offer:

• A collaborative and inclusive workplace that values innovation and diversity.
• Opportunities for professional growth and career advancement in a dynamic industry.
• Competitive compensation and a comprehensive benefits package.
• The chance to contribute to impactful scientific advancements that improve lives.

Application Process:
If you are passionate about leading automation initiatives in a cutting-edge laboratory environment and possess the qualifications outlined above, we encourage you to apply. Please submit your resume and a cover letter detailing your relevant experience and enthusiasm for joining MilliporeSigma.

Pay Range: $137,400-$206,100

The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information click here.

What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!

Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!